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Bone Marrow Biopsy

A myMPNteam Member asked a question 💭
Crestview, FL

So when you had your bone marrow biopsy did you read your report and if so did your diagnosis read like the part I circled red. The reason I ask is because one of my doctors said it’s a standard statement.

September 13, 2023
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A myMPNteam Member

I’m wondering if this is possibly not the final report, because often the pathologist sends a preliminary one to the doctor. Because this report states that the slides are not available for review yet, you will probably not see a section called PERIPHERAL BLOOD SMEAR yet or the ASPIRATE SMEAR. These would be on slides which sometimes take additional time. (This is my guess anyway). It also sounds like this is not a diagnosis set in stone yet, because differential diagnosis means that there may be other conditions with similar findings that still need to be interpreted in collaboration with other factors that the oncologist has in mind. Early primary myelofibrosis is one of the things it could be, but possibly some other factor still needs to be ruled out. I realize that this seems very upsetting to read, but try to be patient until the full discussion with your oncologist brings the report into perspective. (Prayers for an accurate diagnosis and a good treatment plan to be made).

September 13, 2023 (edited)
A myMPNteam Member

Hi JennyLynn,

The results of my bone marrow biopsy were not so elaborate, just had a description of how the bone marrow looks. As my allele burden is 53% (I have ET with MPL mutation), and as some studies were trying to show that higher allele burden means a diagnosis of myelofibrosis is more likely to happen, I asked my hematologist about this and they told me my bone marrow looks OK, and that they always check for signs of myelofibrosis, as this diagnosis (myelofibrosis) is based on bone marrow morphology, not genetic mutation.
If you can, you should ask your hematologist to explain the results to you. It makes much more sense, as the disease is different in different patients.

Best wishes,
Tatiana

September 13, 2023
A myMPNteam Member

        ..tried to get at what you were looking for..my BDBiopsy report:
     “ Consistent with a myeloproliferation neoplasm (MPN) in pre-fibrotic phase.
A primary diagnostic consideration is an essential thrombocythemia (ET),
    however, distinguishing ET and pre-primary myelofibrosis
     (pre-PMF) in early stages of disease can be challenging.
No significant fibrosis. “

September 13, 2023
A myMPNteam Member

I think mine did.

September 13, 2023
A myMPNteam Member

I don't have my full report, but it says "consistent with an MPN, most likely ET". "Normal to slightly hypercellullar BM, megakaryocytes with atypia, in clusters. Mild fibrosis MF1". At the time of my BMB I didn't fill any of the minor criteria for prefibrotic MF, but now, 2 years later, my Hb is 11.5-11.8 and LDH slightly elevated and my hemato says it could be possible, as the BMB report was very vague.

September 14, 2023

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