The same thing happened to me. Do you by chance take Hydroxyurea? That's what caused my severe GI problems. Had tons of tests, with no clear diagnosis for the cause, and after researching a lot, that is my conclusion.

I have heard that a symptom of your disease is stomach upsets that can also lead to reflux. I am taking Nexium to ease the reflux and nausea.

This sounds awful, Ana. It must make it hard for you to get good nutrition.

I don't have any experience with this; maybe someone else will chime in.

Have you been able to talk to your doctors about this very serious problem?

Ana, have you ever been checked for Hpylori? I had those symptoms for a couple of years and when hospitalized 4 years ago I kept insisting they check for that - despite having had over 300 blood tests during that hospital stay they had never checked for Hpylori. It turns out it was positive. Now I am learning that it is more prevalent with people with MPNs.

Regarding thyroid: I've been treated for Hashimoto's thyroiditis for 40 years. 100 mcg of Synthroid has kept my thyroid level normal, ever since the correct dosage was found. Also: Does over-the-counter Bonine help you with nausea? I keep it in my purse for occasional motion sickness. I hope a solution is found for you. Good luck!