Yeah it sounds like to need to see a MPN specialist. You typically need an examination of the actual bone marrow to review the level of fibrosis. That's a crucial report to get. I did my most recent bone marrow biopsy (BMB) under conscious sedation, CT guided. I don't remember anything and recovery was a breeze.

I have residual pain from my bone marrow biopsy. For me, the initial pain was fine, it’s the ongoing that sucks

No bmb, nor has is been suggested. Evidence of JAK2 was all they needed - plus my bloods showed red cells at 221 which was very near death for me, and I could feel my heart almost stop a number of times. Numerous venesections followed, obviously!!! I now suggest to all my friends that annual or bi-annual blood tests are essential and may just save your life. Currently waiting to go on a trial drug in Melbourne 🇦🇺

I had one done by my first Oncologist when I was first diagnosed in 2018, and just had another one ordered by my MPN specialist. First one didn't hurt as much as the second, but he didn't get a very good sample. This time they went in TWO times to get a good sample. It hurt. Two days later, it isn't too bad. I'd do it again if necessary to get the best diagnosis and treatment.

I had a CT-guided BMB to finalize a diagnosis of MF in April 2021. As a Radiologic Technologist, I knew I would have to lay very still. I chose to have sedation (propofol) to not be tempted to move during the procedure. Best decision! Added plus - you don't feel the pain/discomfort or hear what is going on, even though the procedure is quick.