This is really a question for a MPN Specialist to address. You need case specific feedback.

I do not think reasonable doses of Vit B12 would have a dramatic effect on platelet levels. levels. Perhaps if you were very Vit B deficient and already had thrombocytosis there could be atypical impact. However, if you are Vit B deficient, that is a significant health concern in its own right. Deficiencies in the Vit B complex can have very serious negative health impact. There is a risk-benefit assessment that needs to be done in this situation.

You may wish to also consult an Integrative or Functional Medicine doctor about your question, particularly if you are experiencing a Vit B deficiency that needs to be addressed.

Wishing you all the best.

Taking vitamin B12 when being vitamin B12 deficient can temporarily lead to rebound thrombocythemia. This means that platelets increase in number for a while. This should solve itself over time, in theory.
There are other supplements that could also, in theory, increase platelet production, like vitamin C and vitamin K.
We are all very different in our responses. For example, I needed and I took a vitamin B12 supplement, it all went fine. But eating a diet rich in leafy greens (rich in vitamin K) caused me a blood vessel to break twice on my leg and leave me with a serious hematoma. Doctor suspected a blood clot.
Vitamin deficiencies can result in serious health issues and need to be addressed, but as we have a chronic illness, addressing these vitamin deficiencies needs monitoring and caution.
The only supplement I took without issues is vitamin D, as I live in Sweden and I am almost always vitamin D deficient. But this also is not for everyone, especially if people are more prone to kidney stones.

I hope your doctor helps you with this issue. In time we will learn what works and what does not work for our body, as chronic illness does change things for us.

Many hugs of support,
Tatiana

Meats, sea food, eggs, dairy products are full of vitamin b12. I am no longer eating this product and I am not having ET symptoms and my vitamin b12 in my blood is normal because I get it from fruits, nuts, legumes. I don't suffer of fatigue anymore. Not pain in my legs.

Hi BichDiem,
It is exactly what I experienced with my numbers. I will stop b12 and reduce my meats, eggs, sea food, dairy products and you will see the difference in your numbers and how you feel.
I hope this will help you
Best regards
Stephen

I have been taking a Super B complex for probably 10 years, also a women's multi vitamin the past couple of years, with my doctors knowledge and no restrictions.

My platelets have been stable for many years, tho I transformed to PV last year.

I take the supplement because B vitamins are critically important to our body, deficiencies can cause huge issues and I was not getting what I needed from diet.

I believe it is important not to try to manage our MPN’s ourselves, but to consult with our doctors about anything to limit or increase in our diets,

My doctor told me not to take any iron supplements, but what is included in my multi-vit is okay, and stressed the importance of getting adequate protein from meat, fish, eggs, etc.,

Follow your doctors guidance about your diet, and take good care of yourself so you don’t develop other problems.

All the best.