I just recently switched from Jakafi to Ojjaaro. It worked really well for me for almost 3.5 years.

Adding more specifically to my prior post, if Jakafi stops working for you, there are other JAK inhibitors to try. Also, you seem relatively young and may be a good candidate for a transplant. If Jakafi is currently helping you, that’s great - probably too early to worry right now.

I have been on Jakafi fir 6 years.

I had water retention and weight gain issues with Jjakafi. Pretty common and same issues with Molmolitnib which makes me think it was repurposed from Jakafi.

I just had an appointment with my oncologist. She is highly recommending I start Jakafi soon for my enlarged spleen. I don’t really have any serious quality of life issues right now except for some abdominal discomfort after eating related to the enlarged spleen. She thinks I will need a transplant in the next 2-3 years (related to the fact that I have 2 high risk mutations), and said I should not let my spleen get too large as it can be more difficult to reduce it. I will be getting an ultrasound soon to get a benchmark for spleen size. Hopefully I will get good results with no issues when I start.