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I'm ET CALR Type I - Dg Concluded With A BMB Sept 2023. My Platets Start Rising Sept 2021, After 3 Shots Covid Vaccine. What's Your Opinion?

A myMPNteam Member asked a question 💭
Sines
November 3, 2024
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A myMPNteam Member

Hi Veronica. Yes, I think nobody, for now, can correlate one thing to another. But it's a fact, not only for us; I read a lot of stories like ours

November 6, 2024
A myMPNteam Member

I was born with the JAK2 mutation, so not all of these diseases at acquired.

November 5, 2024
A myMPNteam Member

The platelets constantly high and the vaccine: that is just a coincidence.
It has nothing to do with the vaccine. You might have had higher platelets well before the vaccine and just did not catch it with tests. Sometimes people eventually diagnosed with essential thrombocythemia have alternations between normal levels of platelets and high platelets for years before the platelets go high and stay high and one gets diagnosed. You have a pathogenic mutation, CALR type 1, that is what causes your increased platelets.
Given that you have a mutation responsible for your MPN, CALR type 1, your increased platelets are due to the mutation, not the vaccine.
Millions of people take the Covid vaccine, it is a safe vaccine. Do not conflate an MPN that takes years to develop and manifest, which is caused by genetic mutations acquired during lifetime, sometimes even in early childhood, with the temporary increase in platelets that is due to other factors such as anemia due to iron deficiency, infections, surgery, autoimmunity, or the small rise in platelets following a vaccine. Temporary rises in platelets happen, platelets get back to normal values, but these temporary increases are not due to a mutation like the one you have.

Sometimes people acquire a pathogenic mutation like the one you have early in life, but the disease manifests much later. Depending on other factors and the mutation itself, the disease could manifest at any time. And even if you have symptoms much later in life, the mutation causing your disease would have been there for a while before your high platelets were detected.
Also, people with pathogenic CALR mutations tend to get to significantly higher levels of platelets compared to people with other pathogenic mutations that can cause essential thrombocythemia. And that jump does not happen overnight in most people.

"Mutations in CALR are acquired early in the clonal history of the disease, and they cause activation of JAK/STAT signaling."
https://pmc.ncbi.nlm.nih.gov/articles/PMC4222424/

Calreticulin Mutations in Myeloproliferative Neoplasms
Calreticulin Mutations in Myeloproliferative Neoplasms
November 3, 2024 (edited)
A myMPNteam Member

I am not spreading misinformation as you call it. I have my opinion and you have yours. I have shared MY experience and just because you don't agree with that does NOT give you any right to try to discredit MY RESEARCH. You can easily skip past my comments and keep it moving. So your opinion on the vaccine is the RIGHT ONE? Maybe for you but not everyone agrees. You're the one who could use some therapy to help you understand you don't have to like another's opinion. I am past the shock of my diagnosis thank you. I don't need to educate myself to speak my experience. You're spreading HATE by acting like no one can speak about what they have experienced because it differs from YOUR OPINION. I know about the vaccine thank you. I've worked over 20 years in a hospital working with patients everyday. You are not speaking to an uneducated person and I would appreciate if you didn't respond to MY comments any longer. Thank you!

November 7, 2024
A myMPNteam Member

There is not such scientific research as you claim and you are spreading antivaccine conspiracies here.

There is not a single peer reviewed scientific study in a reputable scientific journal that confirms the enormity that vaccines that prevent infections in any way form or shape change our DNA. They do nothing to your DNA. They just help your body, the immune system to be more precise, to make some antibodies to some pathogen, that has nothing to do with your DNA.

And reading some website, a blog, or some dubious antivaccine publication is not reading scientific studies.

You are spreading misinformation and antivaccine conspiracies.
I understand you are upset because you have an MPN, but what good do you think it does to spread antivaccine sentiments here? The vaccine did not cause your illness. The only thing you will achieve is to make people anxious and avoid getting a vaccine that could reduce their chances of severe illness if infected with SARS-COV2. People with MPNs are at higher risk of morbidity and mortality if infected with SARS-COV2. The vaccine reduces that risk.

Kindly talk to a therapist about your difficulties, this diagnosis is heavy, it can be very difficult to come to terms with it, but do not spread antivaccine conspiracy here. Your misinformation might end up harming someone.

November 7, 2024

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