People in this group have different illnesses and different stages of illness. No surprise that reactions to meds differ. In my case, under treatment for ET for 3.5 years and about to turn age 72, I had no trouble with 500 mg HU daily, but disgusting bowel issues throughout 2023, when more HU was added, at first a second capsule two times a week, and then the second capsule three times a week. I got a second opinion and switched to that hematologist/oncologist when my former one wanted to add a fourth day of two capsules. The new one, who is an MPN specialist, disagrees with the former one, who wouldn't prescribe anything other than HU. We've switched to a daily capsule of Anagrelide, which causes me no side effects, plus so far sticking with daily HU plus a second HU twice a week instead of three times a week. I'm hoping we'll be able to eliminate HU altogether, if Anagrelide works as well as HU does to reduce blood platelets. Will know more after next CBC in two weeks.

I thought Hydrea was going to kill me; switched to Pegasys Interferon and what a wonderful difference.

I went from 500 MG of hydroxyurea 1 x day to 500 2 x a day when first diagnosed..I didn't notice anything different side effects

I’m taking 500 mg Hydroxurea every other day. No side effects.
Except lowering platelets.

Glad you feel better..Hopefully feel good for awhile