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Is The Meaning Of VAF 62%, The Length Of Time The PV Was Or Has Been Progressing And Harder To Get Under Control?
It seems as if we have the PV under control (CBC scores wise), but I feel really bad for a couple of weeks, then good for a couple and back to the drawing board with Phlebotomies, then really bad, it goes on and on. Feels like I'm starting over every few months. NOTE: only been at it 7 months.
A VAF is the percentage of mutated cells in that particular sample. Interferons (Pegasys or Besremi) have been shown to lower the percentage of mutated cells in some individuals. My VAF was 29% at diagnosis (03/2019). Started Pegasys 12/2019 with 45 mcg weekly. Dropped to 45 mcg every other week in 2021 and then every three weeks. 08/2022 my VAF was 5%. Just had a blood draw to check it today (will find out in two weeks). Hope this helps!
If your VAF is 62%, it can also mean you might have hereditary PV. Not always, but in younger patients, a VAF >50% at diagnosis indicates some form of hereditary MPN.
Better talk about this with a specialist.
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