The article lists low doses of aspirin as one of the potential sources of relief. This would be accurate. Some find taking low-dose aspirin two times a day rather than one to be helpful for some kinds of pain. Other NDAIDs can be used with caution for pain relief/anti-inflammatory effect. Oral NSAIDs will increase bleeding risk. Best to consult with a MPN Specialist that knows your individual history.

While acetaminophen is a possible option that does not potentiate the blood thinning effect of aspirin, it needs to be used with caution when on cytoreductive medications. many of the cytoreductive agents have liver toxicities as a potential adverse effect. Acetaminophen is also hepatotoxic. Best to consult with a MPN Specialist that knows your individual history.

Many of the things listed in the article can be very helpful. I have found relief with Qigong (Tai Chi), massage therapy, and acupuncture. There are also several anti-inflammatory supplements that have been very helpful, curcumin in particular. Many of these complementary health interventions are effective but many Western-trained doctors are unfamiliar with them. I consult with an Integrative medicine doctors on these interventions.

All the best moving forward.

It only verifies that we are all unique individuals and have different variations of needs and treatments.

Tina2, bless you. So happy you are getting relief and thank you so much for updating how your physician is advising you to take aspirin. I stand corrected. It depends on the patient. Thank you. That is why this site is so good.

It is strange how the article is written. Under treatment for pain of MPN it states for aspirin:
"Aspirin is given in small doses to help prevent the formation of blood clots in the body. Blood clots, which are responsible for some symptoms of MPN, result from the clumping together of platelets." Yes small doses, but then for:
Over-the-Counter Pain Relievers
"Over-the-counter pain relievers, such as aspirin, Advil or Motrin (ibuprofen), or Aleve (naproxen sodium), can help alleviate mild to moderate pain."
If a patient is on 81mg of aspirin twice a day to prevent clots, would the physician approve of the patient then taking 325mg 3 times a day in addition to treat pain?
Yes cytoreductive medication can increase the liver enzymes, usually slightly depending on dosage, but taking acetaminophen below the upper limit per day would be something the physician should be asked about specific for that patient. Just as taking 325mg more of aspirin 3 times a day for pain should be consulted with the physician.
I am just surprised that the article omitted acetaminophen for MPN pain, within limits.

Sorry, Meant to say functional medicine!
Ruth