I was on hydroxyurea for a year and gained 15 lbs. I did not change my exercise or eating routine. I switched to Besremi in March. I have lost 20 lbs. I don’t know why.

Exactly the opposite, I have been losing 3to 5 lbs per month….

Yes I have gained. Nurse practitioner tells me it's not from the HU, but I have asked in an online support group, and yes some people do gain weight on it.

I gained too.

I lost weight while taking hydrea. The weight loss started right away. I sometimes forgot to eat because I didn't feel the normal hunger signals. I started eating more and gained some of the weight back.

This is another example of how our bodies react differently to medications.